Global trial landscape
  • The number of CAR-T & TCR trials initiated continued to grow over the past four years with a 17% compound annual growth rate (CAGR).
  • Despite the growth rate slowing in the last year due to the COVID pandemic, 2020 was another record-breaking year with over 260 trials initiated.
  • Further analysis shows that China has the highest number of CAR-T trials, closely followed by the US.

 

Key players and highlights of the year

Looking at the regulatory movements in the CAR-T & TCR space, 2020 was an exciting year with several players and assets making their presence felt. Kite’s Tecartus was granted approval for mantle cell lymphoma (MCL) both in the US and Europe while liso-cel’s BLA won long-delayed FDA approval for B-cell lymphoma on February 5, 2021. Download the infographic to discover more.

Key Learnings

Although 2020 has been a challenging year due to the COVID pandemic, the cell therapy field continues to expand with China having the most clinical trials.

Kite have further strengthened their position in the field, taking a piece of the MCL market after the approval of Tecartus in the US and Europe. With Breyanzi recently granted FDA approval for B-cell lymphoma, will ide-cel for multiple myeloma be next?

The allogeneic approach is gaining ground in the cell therapy space. While NK cells and T cells offer their own advantages and limitations as “off-the-shelf” therapies, which cell type will eventually be successful?

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