Mapping the Mid-Year Shifts in Targeted Protein Degradation
Targeted protein degradation is building momentum, and 2025 is shaping up to be a landmark year. As of July, Beacon TPD tracks 2,346 assets, with 333 new drugs added in the first half alone – a 16% increase over H1 2024. Clinical activity is also surging, with 234 trial initiations on pace to set a new annual record.
While bivalent degraders continue to lead development, degrader–antibody conjugates (DACs) and molecular glues are showing the fastest growth. Meanwhile, investor focus is shifting, with $2.8B in disclosed deal value reflecting a more selective, data-driven funding environment.
This mid-year review provides unparalleled visibility into the evolving TPD landscape, covering drug and trial trends, emerging targets, deal activity, and regulatory updates that are defining the next phase of this modality.
The Drug Landscape
Explore a pipeline that grew by 330+ TPD drugs in the first half of 2025, with bivalent degraders maintaining dominance and degrader–antibody conjugates (DACs) showing their fastest growth to date.
The Trial Landscape
Track 234 new clinical trials launched so far this year, on pace for a record-setting total, with alloimmune disorders, breast cancer, and lung cancer gaining notable momentum.
The Commercial Landscape
Uncover $2.8B in TPD-related deals at mid-year, as financing, M&A, and targeted licensing agreements shape a more selective investment environment.
Regulatory Announcement
Review recent approvals and global market expansions for therapies like inavolisib and omaveloxolone, signaling broader regulatory acceptance of TPD-based treatments.
The Future of TPD
Examine how novel effectors, from autophagic degradation to alternative E3 ligases, are expanding the reach of targeted protein degradation beyond traditional oncology.
Previous TPD Landscape Reviews
TPD 2024 H1 Landscape Review
An analysis of the TPD landscape in H1 of 2024
TPD 2024 Landscape Review
An analysis of the TPD landscape in 2024
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